AMH Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714759

Recombinant AMH protein expressed in HEK-293 Cells and has been mentioned in 1 publication.

Quick Overview for AMH Protein (Myc-DYKDDDDK Tag) (ABIN2714759)

Target: AMH (Anti-Mullerian Hormone (AMH))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Purification tag / Conjugate: This AMH protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Anti-Muellerian Hormone / AMH protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Signorile, Petraglia, Baldi: "Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells." in: Journal of experimental & clinical cancer research : CR, Vol. 33, pp. 46, (2014) (PubMed).

Target Details

Target: AMH (Anti-Mullerian Hormone (AMH))

Alternative Name: Anti-Muellerian Hormone,amh

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.

Molecular Weight: 56.6 kDa

NCBI Accession: NP_000470

Pathways: Negative Regulation of Hormone Secretion