FKBP4 Protein (Myc-DYKDDDDK Tag)
Quick Overview for FKBP4 Protein (Myc-DYKDDDDK Tag) (ABIN2721214)
Target
See all FKBP4 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This FKBP4 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human FKBP4 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-458) protein (His tag)
custom-made FKBP4 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) protein (His tag)custom-made FKBP4 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) protein (GST tag)FKBP4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
FK506 Binding Protein 4, 59kDa (FKBP4) (AA 1-459) protein (His tag)FKBP4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))
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Alternative Name
- Fkbp4
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Background
- The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
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Molecular Weight
- 51.6 kDa
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NCBI Accession
- NP_002005
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Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
Target
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