MFN2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2726078

Recombinant MFN2 protein expressed in HEK-293 Cells and has been mentioned in 1 publication.

Quick Overview for MFN2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2726078)

Target: MFN2 (Mitofusin 2 (MFN2))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 2

Purification tag / Conjugate: This MFN2 protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Mitofusin-2 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Wang, Zhang, Li, Tang, Siedlak, Fujioka, Liu, Su, Pi, Wang: "MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons." in: The Journal of biological chemistry, Vol. 290, Issue 1, pp. 168-82, (2015) (PubMed).

Target Details

Target: MFN2 (Mitofusin 2 (MFN2))

Alternative Name: Mitofusin-2

Background: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Molecular Weight: 86.2 kDa

NCBI Accession: NP_001121132

Pathways: Skeletal Muscle Fiber Development