PRDM16 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
Quick Overview for PRDM16 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2729560)
Target
See all PRDM16 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 1
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Purification tag / Conjugate
- This PRDM16 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human PRDM16 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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PR Domain Containing 16 (PRDM16) (AA 19-471) protein (His-SUMO Tag)
PRDM16 Origin: Saccharomyces cerevisiae Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
PR Domain Containing 16 (PRDM16) (AA 19-471) protein (His tag)PRDM16 Origin: Saccharomyces cerevisiae Host: Yeast Recombinant > 90 % SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- PRDM16 (PR Domain Containing 16 (PRDM16))
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Alternative Name
- Prdm16
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Background
- The reciprocal translocation t(13)(p36q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Molecular Weight
- 140.1 kDa
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NCBI Accession
- NP_071397
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Pathways
- Stem Cell Maintenance, Brown Fat Cell Differentiation
Target
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