TYMS Protein (Myc-DYKDDDDK Tag)
Quick Overview for TYMS Protein (Myc-DYKDDDDK Tag) (ABIN2733654)
Target
See all TYMS ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This TYMS protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Thymidylate synthase (TS) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Thymidylate Synthetase (TYMS) (AA 1-313) protein (GST tag)
TYMS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Thymidylate Synthetase (TYMS) (AA 1-313) protein (His tag)TYMS Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- TYMS (Thymidylate Synthetase (TYMS))
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Alternative Name
- Thymidylate Synthase (Ts)
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Target Type
- Viral Protein
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Background
- Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
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Molecular Weight
- 35.5 kDa
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NCBI Accession
- NP_001062
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Pathways
- Mitotic G1-G1/S Phases
Target
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