Vitamin D Receptor Protein (VDR) (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2735369

Recombinant Vitamin D Receptor protein expressed in HEK-293 Cells.

Quick Overview for Vitamin D Receptor Protein (VDR) (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2735369)

Target: Vitamin D Receptor (VDR)

Protein Type: Recombinant

Origin: Chemical

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 1

Purification tag / Conjugate: This Vitamin D Receptor protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Vitamin D3 receptor / NR1I1 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Vitamin D Receptor (VDR)

Alternative Name: Vitamin d3 Receptor,nr1i1

Target Type: Chemical

Background: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.

Molecular Weight: 48.1 kDa

NCBI Accession: NP_000367

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway