KAT2A Protein (His tag)
Quick Overview for KAT2A Protein (His tag) (ABIN2745695)
Target
See all KAT2A ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This KAT2A protein is labelled with His tag.
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Purpose
- GCN5 (human) (rec.) (His) (highly active)
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Cross-Reactivity
- Human
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Characteristics
- Human GCN5 is fused to a His-tag.
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Biological Activity Comment
- ~200-300ng are required for standard HAT assay.
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K(lysine) Acetyltransferase 2A (KAT2A) (AA 727-837) protein (His-IF2DI Tag)
KAT2A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
K(lysine) Acetyltransferase 2A (KAT2A) (AA 411-837) protein (His tag)KAT2A Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- In 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride, 0.2 % NP-40, 50 mM imidazole and 10 % glycerol.
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Handling Advice
- After opening, prepare aliquots and store at -80 °C. Avoid freeze/thaw cycles.
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Storage
- -20 °C,-80 °C
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Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -80°C
Use & Stability: Stable for at least 6 months after receipt when stored at -80°C.
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Expiry Date
- 6 months
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- KAT2A (K(lysine) Acetyltransferase 2A (KAT2A))
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Alternative Name
- GCN5
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Background
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GCN5L2, Histone Acetyltransferase GCN5, Histone Acetyltransferase KAT2A, Lysine Acetyltransferase 2A, STAF97
GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. It has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. It regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. GCN5 is a component of the Ada Two-A containing (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4.
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UniProt
- Q92830
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Pathways
- Chromatin Binding, Tube Formation
Target
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