PARP3 Protein (HA tag,His tag)
Quick Overview for PARP3 Protein (HA tag,His tag) (ABIN2745796)
Target
See all PARP3 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This PARP3 protein is labelled with HA tag,His tag.
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Purpose
- PARP-3 [ARTD3] (human) (rec.) (His) (high purity)
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Cross-Reactivity
- Human
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Characteristics
- Human full-length PARP-3 [ARTD3] is fused to a HA-tag and a His-tag.
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Biological Activity Comment
- >10U/mg protein (only monoADP-ribosyl transferase activity).
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Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3) (AA 1-533) protein (His tag)
custom-made PARP3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3) (AA 1-533) protein (GST tag)PARP3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PARP3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- In 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride and 50 mM imidazole, 0.2 % NP-40 and 10 % glycerol.
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Handling Advice
- After opening, prepare aliquots and store at -80 °C. Avoid freeze/thaw cycles.
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Storage
- -20 °C,-80 °C
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Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -80°C
Use & Stability: Stable for at least 6 months after receipt when stored at -80°C.
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Expiry Date
- 6 months
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- PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))
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Alternative Name
- PARP-3 [ARTD3]
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Background
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Poly(ADP-ribose) Polymerase 3, ADP-ribosyltransferase Diphtheria Toxin-like 3, NAD(+) ADP-ribosyltransferase 3
PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
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UniProt
- Q9Y6F1
Target
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