Nerve Growth Factor Protein (NGF) (AA 122-241)
Quick Overview for Nerve Growth Factor Protein (NGF) (AA 122-241) (ABIN2830300)
Target
See all Nerve Growth Factor (NGF) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 122-241
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Sequence
- Ser122-Ala241, Accession # CAA36832
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Characteristics
- Biological Activity: The ED50, as determined by a cell proliferation assay using human TF-1 cells, is less than 2 ng/mL.
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Sterility
- 0.2 μm filtered
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 0.2 % acetic acid
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Storage
- -20 °C
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- Nerve Growth Factor (NGF)
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Alternative Name
- NGF
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Background
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Relevance: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). {ECO:0000269|PubMed:20164177}.
Synonyms: Beta-NGF, -
Molecular Weight
- 13.5 kDa
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UniProt
- P01138
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Pathways
- Regulation of Cell Size
Target
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