DKK1 Protein (AA 32-266)
Quick Overview for DKK1 Protein (AA 32-266) (ABIN2816987)
Target
See all DKK1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
-
-
Protein Characteristics
- AA 32-266
-
Sequence
- Thr32 - His266, Accession # O94907
-
Characteristics
- Biological Activity: The ED50, as determined by inhibition of Wnt-3a induced alkaline phosphatase production using mouse MC3T3E1 cells, is less than 150 ng/mL.
-
Sterility
- 0.2 μm filtered
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His-Avi Tag,Biotin)
DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His tag)DKK1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) protein (Fc-Avi Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (Fc Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) protein (Fc-Avi Tag,Biotin)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) protein (Fc-Avi Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) protein (Fc-Avi Tag,Biotin)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (mFc Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Dickkopf Homolog 1 (DKK1) (AA 1-272) protein (His-IF2DI Tag)DKK1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Buffer
- 20 mM PB, pH 7.4, 150 mM NaCl
-
Storage
- -20 °C
-
-
- DKK1 (Dickkopf Homolog 1 (DKK1))
-
Alternative Name
- DKK1
-
Background
-
Relevance: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Synonyms: Dickkopf-1, hDkk-1, SK -
Molecular Weight
- 25.8 kDa
-
UniProt
- O94907
-
Pathways
- WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Target
-
