DKK1 Protein (AA 32-266)
Quick Overview for DKK1 Protein (AA 32-266) (ABIN2816987)
Target
See all DKK1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 32-266
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Sequence
- Thr32 - His266, Accession # O94907
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Characteristics
- Biological Activity: The ED50, as determined by inhibition of Wnt-3a induced alkaline phosphatase production using mouse MC3T3E1 cells, is less than 150 ng/mL.
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Sterility
- 0.2 μm filtered
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Dickkopf Homolog 1 (DKK1) (AA 32-266) (Active) protein (Biotin,His-Avi Tag)
DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Dickkopf Homolog 1 (DKK1) (AA 32-266) (Active) protein (His tag)DKK1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) (Active) protein (hFc-Avi Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (Fc Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) (Active) protein (hFc-Avi Tag,Biotin)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) (Active) protein (hFc-Avi Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) (Active) protein (hFc-Avi Tag,Biotin)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Dickkopf Homolog 1 (DKK1) (AA 1-242) protein (GST tag)DKK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 81-180) protein (GST tag)DKK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (mFc Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 20 mM PB, pH 7.4, 150 mM NaCl
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Storage
- -20 °C
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- DKK1 (Dickkopf Homolog 1 (DKK1))
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Alternative Name
- DKK1
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Background
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Relevance: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Synonyms: Dickkopf-1, hDkk-1, SK -
Molecular Weight
- 25.8 kDa
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UniProt
- O94907
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Pathways
- WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Target
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