PLG Protein
Quick Overview for PLG Protein (ABIN2830498)
Target
See all PLG ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Sequence
- VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP
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Characteristics
- Biological Activity: Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 x 105 IU/mg.
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Sterility
- 0.2 μm filtered
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Plasminogen (PLG) (AA 98-356) protein (His tag)
PLG Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Plasminogen (PLG) (AA 1-810) protein (GST tag)PLG Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Plasminogen (PLG) (AA 100-352) protein (His tag)PLG Origin: Human Host: Yeast (Pichia pastoris) Recombinant > 95 % WB, SDS, ELISA, IP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 20 mM NaAc, pH 5.5, 4 % mannitol
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Storage
- -20 °C
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- PLG (Plasminogen (PLG))
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Alternative Name
- PLG
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Background
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Relevance: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}., Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.
Synonyms: EC 3.4.21.7, -
Molecular Weight
- 29.7 kDa
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UniProt
- P00747
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Pathways
- Complement System, Lipid Metabolism
Target
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