DKK1 Protein (AA 32-266) (Fc Tag)
Quick Overview for DKK1 Protein (AA 32-266) (Fc Tag) (ABIN2870631)
Target
See all DKK1 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 32-266
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Purification tag / Conjugate
- This DKK1 protein is labelled with Fc Tag.
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Sequence
- AA 32-266
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Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.4 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Dickkopf Homolog 1 (DKK1) (AA 32-266) (Active) protein (Biotin,His-Avi Tag)
DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (Fc Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Dickkopf Homolog 1 (DKK1) (AA 32-266) (Active) protein (His tag)DKK1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) (Active) protein (hFc-Avi Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) (Active) protein (hFc-Avi Tag,Biotin)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) (Active) protein (hFc-Avi Tag,Biotin)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) (Active) protein (hFc-Avi Tag)DKK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Dickkopf Homolog 1 (DKK1) (AA 1-242) protein (GST tag)DKK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 81-180) protein (GST tag)DKK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 1-266) protein (GST tag)DKK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- DKK1 (Dickkopf Homolog 1 (DKK1))
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Alternative Name
- Dkk-1
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Background
- Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.
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Molecular Weight
- 52.4 kDa
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NCBI Accession
- NP_036374
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Pathways
- WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Target
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