ITGAV/ITGB6 Protein (AA 31-992) (His tag)
Quick Overview for ITGAV/ITGB6 Protein (AA 31-992) (His tag) (ABIN2870665)
Target
Protein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 31-992
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Purification tag / Conjugate
- This ITGAV/ITGB6 protein is labelled with His tag.
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Sequence
- AA 31-992
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Characteristics
- Human ITGAV & ITGB6 Heterodimer Protein, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The reducing (R) protein migrates as 145 kDa (ITGAV) and 115 kDa (ITGB6) respectively due to glycosylation.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-988) protein (His tag)
ITGAV/ITGB6 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-993) protein (His tag)ITGAV/ITGB6 Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) protein (His-Avi Tag)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) protein (His-Avi Tag,Biotin)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) (Active) protein (His tag,AVI tag,Biotin)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- ITGAV/ITGB6 (Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6))
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Alternative Name
- Integrin alpha V beta 6
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Background
- Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
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Molecular Weight
- 112.9 kDa (ITGAV) & 79.6 kDa (ITGB6)
Target
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