ITGAV/ITGB6 Protein (His tag)
Quick Overview for ITGAV/ITGB6 Protein (His tag) (ABIN7121505)
Target
Protein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This ITGAV/ITGB6 protein is labelled with His tag.
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Purpose
- Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free
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Sequence
- Phe 31 - Pro 993 (ITGAV) & Gly 22 - Pro 709 (ITGB6)
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Characteristics
- Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-C52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 (ITGAV) & Gly 22 - Pro 709 (ITGB6) (Accession # A0A2K5WCD3-1 (ITGAV) & A0A2K5TZ36-1 (ITGB6).
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-988), (Heterodimer) (Active) protein (His tag)
ITGAV/ITGB6 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992), (Heterodimer) (Active) protein (His-Avi Tag)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-993), (Heterodimer) (Active) protein (His tag)ITGAV/ITGB6 Origin: Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992), (Heterodimer) (Active) protein (Biotin,His-Avi Tag)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) (Active) protein (His tag)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) (AA 31-992) (Active) protein (His tag,AVI tag,Biotin)ITGAV/ITGB6 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by reduced SDS-PAGE. Active
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Application Notes
- Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 113.1 kDa (ITGAV) and 79.0 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 22 (ITGB6). The non-reducing (NR) protein migrates as kDa (ITGAV) & 85-95 kDa (ITGB6) respectively due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM Tris, 150 mM NaCl, pH 8.0
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Storage
- -20 °C
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Storage Comment
- -20°C
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- ITGAV/ITGB6 (Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6))
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Alternative Name
- Integrin alpha V beta 6 (ITGAV&ITGB6)
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Background
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Synonyms: Integrin alpha V beta 6,ITGAV&ITGB6,
Description: Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency-associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1. -
Molecular Weight
- 113.1 kDa (ITGAV) & 79.9 kDa (ITGB6)
Target
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