TIGIT Protein (AA 89-208) (Fc Tag)
Quick Overview for TIGIT Protein (AA 89-208) (Fc Tag) (ABIN4949062)
Target
See all TIGIT ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 89-208
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Purification tag / Conjugate
- This TIGIT protein is labelled with Fc Tag.
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Sequence
- AA 89-208
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Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40 kDa. the protein migrates as 40-50 kDa under reducing (R) condition, and 80-116 kDa under non-reducing (NR) condition (SDS-PAGE).
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (Fc Tag)
TIGIT Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Biotin,His-Avi Tag)TIGIT Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (His tag)TIGIT Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) (Active) protein (His tag)TIGIT Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (mFc Tag)TIGIT Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 89-208) (Active) protein (His tag)TIGIT Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag)TIGIT Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag,AVI tag,Biotin)TIGIT Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (His tag)TIGIT Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
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Alternative Name
- TIGIT
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Background
- T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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Molecular Weight
- 39.9 kDa
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Gene ID
- 18, 17
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NCBI Accession
- XP_015300911
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UniProt
- G7NXM4
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Pathways
- Cancer Immune Checkpoints
Target
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