Synuclein, alpha (SNCA) (full length) (Active) Protein

Details for Product No. ABIN5065824
Protein Name
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein alpha L homeolog
  • alpha-synuclein
  • synuclein alpha
  • synuclein, alpha
  • snca.L
  • LOC619283
  • SNCA
  • Snca
Protein Characteristics
full length
29
10
6
2
1
1
1
1
1
1
1
1
1
1
Origin
Human
45
15
4
1
1
1
1
1
1
1
1
1
1
1
Source
Escherichia coli (E. coli)
47
12
4
2
1
Protein Type
Recombinant
Biological Activity
Active
Application
In vitro Assay (in vitro), In vivo Studies (in vivo), SDS-PAGE (SDS), Western Blotting (WB)
Options
Sequence MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Specificity ~14.46 kDa
Purification Ion-exchange Purified
Purity 92% pure using SDS-PAGE analysis.
Biological Activity Comment Does not induce Lewy body inclusion formation in Sprague-Dawley rat primary hippocampal neurons. Thioflavin T emission curve shows only a small increase in fluorescence (indicative of alpha synuclein aggregation) when Type 2 alpha synuclein PFFs (SPR-317) are combined with alpha synuclein monomers (SPR-321 or SPR-316). Certain biological activities in other neuronal cells cannot be ruled out. Researchers should test compatibility prior to use.
Protein Name
Background Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Molecular Weight 14.46 kDa
Gene ID 6622
NCBI Accession NP_000336
UniProt P37840
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Certified 92% pure using SDS-PAGE analysis.

Restrictions For Research Use only
Concentration Lot specific
Buffer PBS pH 7.4
Storage -80 °C
Supplier Images
Image no. 1 for Synuclein, alpha (SNCA) (full length) (Active) protein (ABIN5065824) SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Aggregate (Control) . L...
Image no. 2 for Synuclein, alpha (SNCA) (full length) (Active) protein (ABIN5065824) Primary rat hippocampal neurons show lewy body inclusion formation when treated with ...
Image no. 3 for Synuclein, alpha (SNCA) (full length) (Active) protein (ABIN5065824) Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregat...