NMNAT2 Protein (AA 2-307) (His tag)
Quick Overview for NMNAT2 Protein (AA 2-307) (His tag) (ABIN5564378)
Target
See all NMNAT2 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 2-307
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Purification tag / Conjugate
- This NMNAT2 protein is labelled with His tag.
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Purpose
- NMNAT2 (human) (rec.) (His)
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Cross-Reactivity
- Human
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Characteristics
- Human NMNA2 (aa 2-307) is fused at the N-terminus to a His-tag.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- 0.1 mg/mL
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Buffer
- Lyophilized in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl plus 0.025 % CHAPS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))
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Alternative Name
- NMNAT2
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Background
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Nicotinamide Mononucleotide Adenylyltransferase 2, NMN Adenylyltransferase 2, NaMN Adenylyltransferase 2
Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. NMNAT2 also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. It is highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. NMNAT2 is also found in the heart, skeletal muscle, pancreas and islets of Langerhans. NMNAT2 is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration (axon degeneration induced by nerve injury), whereas NMNAT overexpression rescues axons from degeneration.
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Molecular Weight
- ~35kDa (SDS-PAGE)
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UniProt
- Q9BZQ4
Target
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