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NMNAT2 Protein (AA 2-307) (His tag)

Recombinant NMNAT2 protein expressed in Escherichia coli (E. coli).
Catalog No. ABIN5564378
$284.06
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 5 to 10 Business Days

Quick Overview for NMNAT2 Protein (AA 2-307) (His tag) (ABIN5564378)

Target

See all NMNAT2 Proteins
NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Protein Type

Recombinant

Origin

  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Source

  • 4
  • 3
  • 2
  • 2
  • 1
Escherichia coli (E. coli)

Application

SDS-PAGE (SDS)

Purity

>90 % (SDS-PAGE)
  • Protein Characteristics

    AA 2-307

    Purification tag / Conjugate

    This NMNAT2 protein is labelled with His tag.

    Purpose

    NMNAT2 (human) (rec.) (His)

    Cross-Reactivity

    Human

    Characteristics

    Human NMNA2 (aa 2-307) is fused at the N-terminus to a His-tag.
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  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Concentration

    0.1 mg/mL

    Buffer

    Lyophilized in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl plus 0.025 % CHAPS.

    Handling Advice

    After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.

    Storage

    4 °C,-20 °C

    Storage Comment

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

    Expiry Date

    6 months
  • Target

    NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

    Alternative Name

    NMNAT2

    Background

    Nicotinamide Mononucleotide Adenylyltransferase 2, NMN Adenylyltransferase 2, NaMN Adenylyltransferase 2

    Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. NMNAT2 also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. It is highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. NMNAT2 is also found in the heart, skeletal muscle, pancreas and islets of Langerhans. NMNAT2 is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration (axon degeneration induced by nerve injury), whereas NMNAT overexpression rescues axons from degeneration.

    Molecular Weight

    ~35kDa (SDS-PAGE)

    UniProt

    Q9BZQ4
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