Granulin Protein (GRN) (AA 1-602)
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- Target See all Granulin (GRN) Proteins
- Granulin (GRN)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-602
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Origin
- Rat
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Source
- HEK-293 Cells
- Application
- SDS-PAGE (SDS)
- Purpose
- Progranulin (rat) (rec.) (untagged)
- Cross-Reactivity
- Rat
- Characteristics
- Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
- Top Product
- Discover our top product GRN Protein
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Granulin (GRN) (AA 494-593) protein (GST tag)
GRN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 1-593) protein (GST tag)GRN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 364-430) protein (His tag)GRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) protein (His tag)GRN Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Contains PBS.
- Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Centrifuge lyophilized vial before opening and reconstitution. Do not freeze/thaw. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Expiry Date
- 6 months
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- Target
- Granulin (GRN)
- Alternative Name
- Progranulin (GRN Products)
- Background
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Proepithelin, PEPI, PC Cell-derived Growth Factor
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
- Molecular Weight
- ~73kDa (SDS-PAGE)
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