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Granulin Protein (GRN) (AA 1-602) (DYKDDDDK Tag)

GRN Origin: Rat Host: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS
Catalog No. ABIN1344102
  • Target See all Granulin (GRN) Proteins
    Granulin (GRN)
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-602
    Origin
    • 16
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Source
    • 9
    • 7
    • 7
    • 3
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This Granulin protein is labelled with DYKDDDDK Tag.
    Application
    SDS-PAGE (SDS)
    Cross-Reactivity
    Rat (Rattus)
    Characteristics
    Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.
    Purity
    >95 % (SDS-PAGE)
    Sterility
    0.2 μm filtered
    Endotoxin Level
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product GRN Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized from 0.2μm-filtered solution in PBS.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Target
    Granulin (GRN)
    Alternative Name
    Progranulin (GRN Products)
    Synonyms
    GRN Protein, grn Protein, wu:fb11g12 Protein, wu:fj18f05 Protein, MGC53354 Protein, DKFZp459H066 Protein, CLN11 Protein, GEP Protein, GP88 Protein, PCDGF Protein, PEPI Protein, PGRN Protein, epithelin Protein, acrogranin Protein, granulin precursor Protein, granulin a Protein, Granulins Protein, granulin L homeolog Protein, granulin Protein, GRN Protein, grna Protein, grn Protein, grn.L Protein, granulin Protein, ORF1 granulin Protein, Grn Protein
    Target Type
    Viral Protein
    Background
    Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
    Molecular Weight
    ~65kDa (SDS-PAGE)
    NCBI Accession
    NP_058809
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