Granulin Protein (GRN) (AA 1-593)
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- Target See all Granulin (GRN) Proteins
- Granulin (GRN)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 1-593
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Origin
- Human
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Source
- HEK-293 Cells
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Human
- Characteristics
- Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product GRN Protein
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Granulin (GRN) (AA 494-593) protein (GST tag)
GRN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 364-430) protein (His tag)GRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) (AA 1-593) protein (GST tag)GRN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Granulin (GRN) protein (His tag)GRN Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).
- Restrictions
- For Research Use only
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- Format
- Solid
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. - Expiry Date
- 6 months
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- Target
- Granulin (GRN)
- Alternative Name
- Progranulin (GRN Products)
- Synonyms
- GRN Protein, grn Protein, wu:fb11g12 Protein, wu:fj18f05 Protein, MGC53354 Protein, DKFZp459H066 Protein, CLN11 Protein, GEP Protein, GP88 Protein, PCDGF Protein, PEPI Protein, PGRN Protein, epithelin Protein, acrogranin Protein, granulin precursor Protein, granulin a Protein, Granulins Protein, granulin L homeolog Protein, granulin Protein, GRN Protein, grna Protein, grn Protein, grn.L Protein, granulin Protein, ORF1 granulin Protein, Grn Protein
- Target Type
- Viral Protein
- Background
- Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
- Molecular Weight
- ~74kDa (glycosylated protein by SDS-PAGE)
- UniProt
- P28799
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