IL1F10 Protein (His tag)
Quick Overview for IL1F10 Protein (His tag) (ABIN5564483)
Target
See all IL1F10 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This IL1F10 protein is labelled with His tag.
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Purpose
- IL-38 (aa 20-152) (human) (rec.) (His)
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Cross-Reactivity
- Human
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Characteristics
- Human IL-38 (aa Leu20-Trp152) is fused at the C-terminus to a His-tag.
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Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
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Interleukin 1 Family, Member 10 (Theta) (IL1F10) (AA 1-152) protein (His tag)
custom-made IL1F10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Interleukin 1 Family, Member 10 (Theta) (IL1F10) (AA 1-152) protein (His tag)custom-made IL1F10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Interleukin 1 Family, Member 10 (Theta) (IL1F10) proteinIL1F10 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by reducing SDS-PAGE. IA, AM, ADA, ScA
Interleukin 1 Family, Member 10 (Theta) (IL1F10) (AA 1-152) protein (His tag)IL1F10 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- Lot specific
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Buffer
- Contains PBS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))
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Alternative Name
- IL-38
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Background
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Interleukin-38, Interleukin-1 Family Member 10, IL-1F10
IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1, TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
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Molecular Weight
- ~16kDa
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UniProt
- Q8WWZ1
Target
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