ACVA Protein (partial)

Catalog No. ABIN5608399

This Recombinant ACVA protein is expressed in HEK-293 Cells.

Quick Overview for ACVA Protein (partial) (ABIN5608399)

Target: ACVA (Activin A (ACVA))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Application: Western Blotting (WB), ELISA

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: partial

Sequence: Gly 311 - Ser 426

Endotoxin Level: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Biological Activity Comment:

Measured by its binding ability in a functional ELISA. Immobilized Human Activin A, Tag Free at 10 μg/mL (100 uL/well) can bind Human ACVR1B, Fc Tag with a linear range of 0.3-2.5 μg/mL (QC tested).

Application Details

Application Notes: This recombinant protein can be used for E, WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.056 % TFA in 60 % ACN

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Target Details

Target: ACVA (Activin A (ACVA))

Alternative Name: Activin A

Background: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various beta subunits (betaA, betaB, betaC, and betaE in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two betaA chains. The betaA subunit can also heterodimerize with a betaB or betaC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human betaA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat betaA.

Molecular Weight: 13 kDa

Gene ID: 3624

UniProt: P08476

Pathways: Hormone Transport, Peptide Hormone Metabolism