RANKL Protein (AA 64-245) (His tag)
Quick Overview for RANKL Protein (AA 64-245) (His tag) (ABIN5674645)
Target
See all RANKL (TNFSF11) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 64-245
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Purification tag / Conjugate
- This RANKL protein is labelled with His tag.
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Sequence
- AA 64-245
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Characteristics
- This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 23.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 63-244) protein (His-DYKDDDDK Tag)
TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 63-244) proteinTNFSF11 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-316) protein (His tag)custom-made TNFSF11 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) protein (His tag)custom-made TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 70-316) protein (His tag)TNFSF11 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 158-317) protein (His-DYKDDDDK-Strep II Tag)TNFSF11 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 64-245) protein (Fc Tag)TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 64-245) (Active) protein (AVI tag,Fc Tag,Biotin)TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 64-245) (Active) protein (His tag,AVI tag,Biotin)TNFSF11 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
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Alternative Name
- TNFSF11
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Background
- Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
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Molecular Weight
- 22.4 kDa
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Pathways
- NF-kappaB Signaling
Target
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