GDF5 Protein (AA 376-495) (His tag)
Quick Overview for GDF5 Protein (AA 376-495) (His tag) (ABIN5709563)
Target
See all GDF5 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 376-495
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Purification tag / Conjugate
- This GDF5 protein is labelled with His tag.
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Sequence
- APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
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Purification
- SDS-PAGE
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Growth Differentiation Factor 5 (GDF5) (AA 376-495) protein (His-IF2DI Tag)
GDF5 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Growth Differentiation Factor 5 (GDF5) (AA 382-501) protein (His-IF2DI Tag)GDF5 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Growth Differentiation Factor 5 (GDF5) (AA 28-127) protein (GST tag)GDF5 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Growth Differentiation Factor 5 (GDF5) (AA 376-495) protein (His tag)GDF5 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Growth Differentiation Factor 5 (GDF5) proteinGDF5 Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
Growth Differentiation Factor 5 (GDF5) proteinGDF5 Origin: Human Host: Escherichia coli (E. coli) Recombinant 98,00% SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.1-2 mg/mL
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Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
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Storage
- -80 °C,4 °C,-20 °C
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Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- GDF5 (Growth Differentiation Factor 5 (GDF5))
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Alternative Name
- GDF5
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Background
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 . Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes .
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Molecular Weight
- 17.7 kDa
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UniProt
- P43027
Target
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