HMGCR Protein (AA 588-887, partial) (His tag)
Quick Overview for HMGCR Protein (AA 588-887, partial) (His tag) (ABIN5709669)
Target
See all HMGCR ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- partial, AA 588-887
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Purification tag / Conjugate
- This HMGCR protein is labelled with His tag.
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Sequence
- MTRGPVVRLP RACDSAEVKA WLETSEGFAV IKEAFDSTSR FARLQKLHTS IAGRNLYIRF QSRSGDAMGM NMISKGTEKA LSKLHEYFPE MQILAVSGNY CTDKKPAAIN WIEGRGKSVV CEAVIPAKVV REVLKTTTEA MIEVNINKNL VGSAMAGSIG GYNAHAANIV TAIYIACGQD AAQNVGSSNC ITLMEASGPT NEDLYISCTM PSIEIGTVGG GTNLLPQQAC LQMLGVQGAC KDNPGENARQ LARIVCGTVM AGELSLMAAL AAGHLVKSHM IHNRSKINLQ DLQGACTKKT
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Purification
- SDS-PAGE
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3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 1-887) protein (His tag)
custom-made HMGCR Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 1-888) protein (His tag)custom-made HMGCR Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 700-860) protein (His tag)HMGCR Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 1-835) protein (GST tag)HMGCR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.1-2 mg/mL
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Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
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Storage
- -80 °C,4 °C,-20 °C
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Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
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Alternative Name
- HMDH
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Background
- Transmbrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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Molecular Weight
- 36.1 kDa
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UniProt
- P04035
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Pathways
- AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
Target
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