PABP Protein (AA 1-370, partial) (His-SUMO Tag)
Quick Overview for PABP Protein (AA 1-370, partial) (His-SUMO Tag) (ABIN5710061)
Target
See all PABP (PABPC1) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-370, partial
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Purification tag / Conjugate
- This PABP protein is labelled with His-SUMO Tag.
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Sequence
- MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE AELGARAKEF TNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT KPLYVALAQR
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Purification
- SDS-PAGE
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Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 1-636) protein (His tag)
custom-made PABPC1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 1-636) protein (His tag)custom-made PABPC1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 1-636) protein (GST tag)PABPC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) (AA 2-235) protein (His-IF2DI Tag)PABPC1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) protein (Myc-DYKDDDDK Tag)PABPC1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.1-2 mg/mL
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Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
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Storage
- -80 °C,4 °C,-20 °C
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Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))
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Alternative Name
- PABP1
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Background
- Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing prature stop codons, for the recognition of prature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.
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Molecular Weight
- 57.8 kDa
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UniProt
- P11940
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Pathways
- SARS-CoV-2 Protein Interactome
Target
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