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TRIM24 Protein (AA 891-1012, partial) (His-SUMO Tag)

Recombinant TRIM24 protein expressed in Escherichia coli (E. coli).
Catalog No. ABIN5710552
$488.40
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Quick Overview for TRIM24 Protein (AA 891-1012, partial) (His-SUMO Tag) (ABIN5710552)

Target

See all TRIM24 Proteins
TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Protein Type

Recombinant

Origin

  • 6
  • 2
Human

Source

  • 2
  • 2
  • 2
  • 1
  • 1
Escherichia coli (E. coli)

Application

SDS-PAGE (SDS)

Purity

> 90 %
  • Protein Characteristics

    AA 891-1012, partial

    Purification tag / Conjugate

    This TRIM24 protein is labelled with His-SUMO Tag.

    Sequence

    KKKTEGLVKL TPIDKRKCER LLLFLYCHEM SLAFQDPVPL TVPDYYKIIK NPMDLSTIKK RLQEDYSMYS KPEDFVADFR LIFQNCAEFN EPDSEVANAG IKLENYFEEL LKNLYPEKRF PK

    Purification

    SDS-PAGE
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    Expression System
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    Expression System HEK-293 Cells
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    Origin Human
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  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.1-2 mg/mL

    Buffer

    20 mM Tris-HCl based buffer, pH 8.0

    Storage

    -80 °C,4 °C,-20 °C

    Storage Comment

    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target

    TRIM24 (Tripartite Motif Containing 24 (TRIM24))

    Alternative Name

    TIF1A

    Background

    Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes .

    Molecular Weight

    30.47 kDa

    UniProt

    O15164
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