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- Target See all FHIT Proteins
- FHIT (Fragile Histidine Triad (FHIT))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-150
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Origin
- Mouse
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Source
- Yeast
- Purification tag / Conjugate
- This FHIT protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- SFRFGQHLIK PSVVFLKTEL SFALVNRKPV VPGHVLVCPL RPVERFRDLH PDEVADLFQV TQRVGTVVEK HFQGTSITFS MQDGPEAGQT VKHVHVHVLP RKAGDFPRND NIYDELQKHD REEEDSPAFW RSEKEMAAEA EALRVYFQA
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product FHIT Protein
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Fragile Histidine Triad (FHIT) (AA 1-147) protein (His tag)
FHIT Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Fragile Histidine Triad (FHIT) (AA 31-130) protein (GST tag)FHIT Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Fragile Histidine Triad (FHIT) (AA 1-150) protein (Strep Tag)Crystallography grade FHIT Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Fragile Histidine Triad (FHIT) (AA 2-147), (full length) protein (His tag)FHIT Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA
Fragile Histidine Triad (FHIT) (AA 2-150) protein (His tag)FHIT Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Fragile Histidine Triad (FHIT) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)FHIT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- FHIT (Fragile Histidine Triad (FHIT))
- Alternative Name
- FHIT (FHIT Products)
- Synonyms
- AP3Aase Protein, FRA3B Protein, FHIT Protein, zgc:73176 Protein, AW045638 Protein, Fra14A2 Protein, LOC100223655 Protein, fragile histidine triad Protein, fragile histidine triad gene Protein, fragile histidine triad protein Protein, fragile histidine triad L homeolog Protein, FHIT Protein, Fhit Protein, fhit Protein, PY07476 Protein, fhit.L Protein
- Background
- Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extrely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity . Functions as tumor suppressor.
- Molecular Weight
- 19.1 kDa
- UniProt
- O89106
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