Hemopexin Protein (HPX) (AA 24-462) (His tag)
Quick Overview for Hemopexin Protein (HPX) (AA 24-462) (His tag) (ABIN5853547)
Target
See all Hemopexin (HPX) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 24-462
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Purification tag / Conjugate
- This Hemopexin protein is labelled with His tag.
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Sequence
- MGSSHHHHHH SSGLVPRGSH MGSTPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA FRQGHNSVFL IKGDKVWVYP PEKKEKGYPK LLQDEFPGIP SPLDAAVECH RGECQAEGVL FFQGDREWFW DLATGTMKER SWPAVGNCSS ALRWLGRYYC FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN GTGHGNSTHH GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG TPHGIILDSV DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH EKVDGALCME KSLGPNSCSA NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ PQNVTSLLGC TH
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Hemopexin (HPX) (AA 24-460) protein (His tag)
HPX Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hemopexin (HPX) (AA 24-462) protein (His tag)HPX Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hemopexin (HPX) (AA 24-462) protein (His tag)HPX Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hemopexin (HPX) (AA 24-460) protein (His tag)HPX Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Hemopexin (HPX) (AA 1-254) protein (GST tag)HPX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Hemopexin (HPX) (Active) protein (His tag)HPX Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
Hemopexin (HPX) proteinHPX Origin: Human Host: Human Native >95 %
Hemopexin (HPX) (AA 24-460), (full length) protein (His tag)HPX Origin: Rat Host: Yeast Recombinant > 90 % ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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Denatured
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Hemopexin (HPX)
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Alternative Name
- HPX
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Background
- Hemopexin precursor, also known as HPX, is a serum glycoprotein that binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. It is expressed by the liver and is secreted in plasma. Hemopexin may play a role in the maintenance of metal ion homeostasis. HPX can also act as a toxic protease that leads to proteinuria and glomerular alterations, which are characteristics of minimal changes disease (MCD), a common cause of nephrotic syndrome. Recombinant human HPX protein, fused to His-tag at N-terminus, was expressed in E.coli.
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Molecular Weight
- 51.7 kDa (462aa)
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NCBI Accession
- NP_000604
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UniProt
- P02790
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Pathways
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Target
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