Hemopexin Protein (HPX) (AA 24-462) (His tag)
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- Target See all Hemopexin (HPX) Proteins
- Hemopexin (HPX)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-462
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Origin
- Cynomolgus
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Hemopexin protein is labelled with His tag.
- Purpose
- Cynomolgus HPX Protein
- Sequence
- Asn24-Tyr462
- Characteristics
- Recombinant Cynomolgus HPX Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asn24-Tyr462.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product HPX Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in 20 mM MES, 150 mM NaCl ( pH 6.0).
- Buffer
- Lyophilized from 0.22μm filtered solution in 20 mM MES, 150 mM NaCl ( pH 6.0). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Hemopexin (HPX)
- Alternative Name
- HPX (HPX Products)
- Synonyms
- HPX Protein, HX Protein, Hpxn Protein, hx Protein, wu:fi17f11 Protein, wu:fi19a10 Protein, hemopexin Protein, HPX Protein, Mmar10_1124 Protein, Hpx Protein, hpx Protein
- Background
- Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-protein.
- Molecular Weight
- 50.30 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.
- UniProt
- A0A2K5WVL1
- Pathways
- Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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