Ganciclovir Protein

Catalog No. ABIN624143

This Synthetic Ganciclovir protein is expressed in not_set.

Quick Overview for Ganciclovir Protein (ABIN624143)

Target: Ganciclovir

Protein Type: Synthetic

Origin: Synthetic

Host: Please inquire

Purity: > 99.0 %.

Product Details

Characteristics: Ganciclovir

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is recommended to reconstitute the lyophilized Ganciclovir in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage: 4 °C

Target Details

Target: Ganciclovir

Background: Ganciclovir is a white to off-white crystalline powder with a molecular formula of C9H13N504 and a molecular weight of 255.23. Introduction: Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Ganciclovir is a synthetic analogue of 2'-deoxy-guanosine. It is initially phosphorylated to a deoxyguanosine triphosphate (dGTP) analogue. This mechanism competitively inhibits the integration of dGTP by viral DNA polymerase, resulting in the termination of elongation of viral DNA. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Synonyms: Histone H3-like centromeric protein A, Centromere protein A, CENP-A, Centromere autoantigen A, CENPA.