IL-24 Protein (AA 53-207) (Fc Tag)
Quick Overview for IL-24 Protein (AA 53-207) (Fc Tag) (ABIN6253245)
Target
See all IL-24 (IL24) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 53-207
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Purification tag / Conjugate
- This IL-24 protein is labelled with Fc Tag.
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Purpose
- IL-24 (human):Fc (human) (rec.)
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Specificity
- The extracellular domain of human IL-24 (aa 53-207) is fused to the N-terminus of the Fc region of a human IgG1.
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Characteristics
- Protein. The extracellular domain of human IL-24 (aa 53-207) is fused to the N-terminus of the Fc region of a human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. It is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. IL-24 has antiproliferative properties is inhibiting angiogenesis and may contribute to terminal cell differentiation.
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Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
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Interleukin 24 (IL24) (AA 51-206) (Active) protein (His tag)
IL24 Origin: Human Host: Escherichia coli (E. coli) > 90 % AcA, CC Active
Interleukin 24 (IL24) (AA 1-206) protein (GST tag)IL24 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 24 (IL24) (AA 58-167) protein (GST tag)IL24 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 24 (IL24) (AA 1-207) protein (GST tag)IL24 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- Lot specific
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Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
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Handling Advice
- Avoid freeze/thaw cycles.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- IL-24 (IL24) (Interleukin 24 (IL24))
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Alternative Name
- IL-24
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Background
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Alternate Names/Synonyms: Interleukin-24, MDA7, ST16
Product Description: IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. It is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. IL-24 has antiproliferative properties is inhibiting angiogenesis and may contribute to terminal cell differentiation.
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagy
Target
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