IL-10RA Protein (AA 22-235) (Fc Tag)
Quick Overview for IL-10RA Protein (AA 22-235) (Fc Tag) (ABIN6253272)
Target
See all IL-10RA (IL10RA) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 22-235
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Purification tag / Conjugate
- This IL-10RA protein is labelled with Fc Tag.
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Purpose
- IL-10Ralpha (human):Fc (human) (rec.)
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Specificity
- The extracellular domain of human IL-10Ralpha (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1.
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Characteristics
- Protein. The extracellular domain of human IL-10Ralpha (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
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Endotoxin Level
- <5EU/mg protein (LAL test, Lonza).
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Biological Activity Comment
- Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.
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Interleukin 10 Receptor, alpha (IL10RA) (AA 22-235) (Active) protein (His-Avi Tag)
IL10RA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 10 Receptor, alpha (IL10RA) (AA 22-233) (Active) protein (His tag)IL10RA Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- Lot specific
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Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
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Handling Advice
- Avoid freeze/thaw cycles.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
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Alternative Name
- IL-10Ralpha
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Background
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Alternate Names/Synonyms: Interleukin-10 Receptor alpha, IL-10RA, CD210, IL-10R1, CDw210a,
Product Description: CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
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Molecular Weight
- ~70kDa (SDS-PAGE)
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Pathways
- Growth Factor Binding
Target
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