Interleukin 17a Protein (AA 20-155) (Fc Tag)

Catalog No. ABIN6253274

Recombinant Interleukin 17a protein expressed in HEK-293 Cells.

Quick Overview for Interleukin 17a Protein (AA 20-155) (Fc Tag) (ABIN6253274)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >98 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 20-155

Purification tag / Conjugate: This Interleukin 17a protein is labelled with Fc Tag.

Purpose: IL-17A (human):Fc (human) (rec.) (non-lytic)

Specificity: The extracellular domain of human IL-17A (aa 20-155) is fused to the N-terminus of the Fc region of mutant human IgG1.

Characteristics: Protein. The extracellular domain of human IL-17A (aa 20-155) is fused to the N-terminus of the Fc region of mutant human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg purified protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblsts, the enhancement of surface expression of ICAM-1 in fibroblast, activation of NF-kappaB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.

Endotoxin Level: <5EU/mg purified protein (LAL test, Lonza).

Biological Activity Comment: Measured by its ability to induce IL-6 secretion.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: IL-17A

Background:

Alternate Names/Synonyms: Interleukin-17A, Cytotoxic T-lymphocyte-associated Antigen 8, CTLA-8

Product Description: Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblsts, the enhancement of surface expression of ICAM-1 in fibroblast, activation of NF-kappaB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.

Molecular Weight: ~42kDa (SDS-PAGE)