CD74 Protein (AA 56-215) (Fc Tag)
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- Target See all CD74 Proteins
- CD74 (HLA-DR-gamma (CD74))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 56-215
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD74 protein is labelled with Fc Tag.
- Purpose
- CD74 (mouse):Fc (mouse) (rec.)
- Specificity
- The extracellular domain of mouse CD74 (aa 56-215) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Characteristics
- Protein. The extracellular domain of mouse CD74 (aa 56-215) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD74 is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. The cytoplasmic portion of CD74 can be released by intramembrane cleavage to activate NFkB. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <5EU/mg protein (LAL test, Lonza).
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HLA-DR-gamma (CD74) (AA 73-232) protein (His tag)
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HLA-DR-gamma (CD74) protein (Fc Tag)CD74 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- CD74 (HLA-DR-gamma (CD74))
- Alternative Name
- CD74 (CD74 Products)
- Background
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Alternate Names/Synonyms: CLIP, DHLAG, HLADG
Product Description: CD74 is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. The cytoplasmic portion of CD74 can be released by intramembrane cleavage to activate NFkB. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation.
- Molecular Weight
- ~55kDa (SDS-PAGE)
- NCBI Accession
- NP_034675
- Pathways
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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