CD74 Protein (AA 73-296) (His tag)

Catalog No. ABIN7504958

This Recombinant CD74 protein is expressed in Escherichia coli (E. coli).

Quick Overview for CD74 Protein (AA 73-296) (His tag) (ABIN7504958)

Target: CD74 (HLA-DR-gamma (CD74))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Immunogen (Imm)

Purity: > 90 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 73-296

Purification tag / Conjugate: This CD74 protein is labelled with His tag.

Sequence: Gln73-Met296

Characteristics: A DNA sequence encoding theHuman CD74 protein (P04233) (73Q-296M) was expressed with a polyhistidine tag at the N-terminus.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

used as Immunogen for (ABIN6999918, ABIN7234286, ABIN7234287 and ABIN7234288)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CD74 (HLA-DR-gamma (CD74))

Alternative Name: CD74

Background:

Abbreviation: CD74

Target Synonym: CD 74,CD74 antigen (invariant polypeptide of major histocompatibility complex,class II antigen-associated),CD74 Molecule,major histocompatibility complex,class II invariant chain,CLIP,DHLAG,Gamma chain of class II antigens,HG2A,HLA class II histocompatibility antigen gamma chain,HLA DR antigens associated invariant chain,HLA DR gamma,HLA-DR antigens-associated invariant chain,HLA-DR-gamma,HLADG,HLADR antigens associated invariant chain,Ia antigen associated invariant chain,Ia antigen-associated invariant chain,Ia associated invariant chain,Ia gamma,Invariant polypeptide of major histocompatibility complex class II antigen associated,la-gamma,Major histocompatibility complex class II invariant chain,MHC HLA DR gamma chain,MHC HLA-DR gamma chain,p33,p35,Protein 41

Background: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Molecular Weight:

Calculated MW: 26.6 kDa

Observed MW: 30-33 kDa

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints