TNFRSF4 Protein (AA 20-211) (Fc Tag)

Catalog No. ABIN6253312

This Recombinant TNFRSF4 protein is expressed in HEK-293 Cells.

Quick Overview for TNFRSF4 Protein (AA 20-211) (Fc Tag) (ABIN6253312)

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: >98 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 20-211

Purification tag / Conjugate: This TNFRSF4 protein is labelled with Fc Tag.

Purpose: CD134 [OX40] (mouse):Fc (human) (rec.)

Specificity: The extracellular domain of mouse CD134 (aa 20-211) is fused to the N-terminus of the Fc region of human IgG1.

Characteristics: Protein. The extracellular domain of mouse CD134 (aa 20-211) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.

Endotoxin Level: <5EU/mg protein (LAL test, Lonza).

Biological Activity Comment: Measured by its binding ability in a functional ELISA.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Alternative Name: CD134 [OX40]

Background:

Alternate Names/Synonyms: OX40, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, ACT35, TXGP1L

Product Description: CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.

Molecular Weight: ~68kDa (SDS-PAGE)

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints