VSIG4 Protein (AA 20-283) (Fc Tag)

Catalog No. ABIN6253409

Recombinant VSIG4 protein expressed in HEK-293 Cells.

Quick Overview for VSIG4 Protein (AA 20-283) (Fc Tag) (ABIN6253409)

Target: VSIG4 (V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >98 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 20-283

Purification tag / Conjugate: This VSIG4 protein is labelled with Fc Tag.

Purpose: VSIG4 (human):Fc (mouse) (rec.)

Specificity: The extracellular domain of human VSIG4 (aa 20-283) is fused to the N-terminus of the Fc region of mouse IgG2a.

Characteristics: Protein. The extracellular domain of human VSIG4 (aa 20-283) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.

Endotoxin Level: <0.06EU/μg protein (LAL test, Lonza).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: VSIG4 (V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4))

Alternative Name: VSIG4

Background:

Alternate Names/Synonyms: V-set and immunoglobulin domain containing 4, Z39Ig, CRIg

Product Description: VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.

Molecular Weight: ~68kDa (SDS-PAGE)

UniProt: Q9Y279