TNFSF4 Protein (AA 50-183) (Fc Tag)

Catalog No. ABIN6253461

This Recombinant TNFSF4 protein is produced in HEK-293 Cells.

Quick Overview for TNFSF4 Protein (AA 50-183) (Fc Tag) (ABIN6253461)

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >95 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 50-183

Purification tag / Conjugate: This TNFSF4 protein is labelled with Fc Tag.

Purpose: Fc (human):OX40L, Soluble (human) (rec.)

Specificity: The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1.

Cross-Reactivity: Human

Characteristics: The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1.

Endotoxin Level: <0.01EU/μg purified protein (LAL test).

Biological Activity Comment: Activates T cell proliferation.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: 0.1 mg/mL

Buffer: Contains PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Expiry Date: 6 months

Target Details

Target: TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))

Alternative Name: :OX40L

Background:

CD252, CD134L, OX40 Ligand, TNFSF4, Tumor Necrosis Factor Superfamily Member 4, TAX Transcriptionally-activated Glycoprotein 1, TXGP1, Gp34

OX40L [CD252, TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Fc (human):OX40L, Soluble (human) (rec.) is a high activity construct in which two trimeric OX40L ligands are artificially linked via the Fc domain of human immunoglobulin.

Molecular Weight: ~50kDa (SDS-PAGE)

UniProt: P23510

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints