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Liver Arginase Protein (active Mutant)

ARG1 Origin: Human Host: Escherichia coli (E. coli) Recombinant >90 % (SDS-PAGE)
Catalog No. ABIN6253489
  • Target See all Liver Arginase (ARG1) Proteins
    Liver Arginase (ARG1) (Arginase, Liver (ARG1))
    Protein Type
    Recombinant
    Protein Characteristics
    active Mutant
    Origin
    • 8
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 6
    • 5
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purpose
    Arginase I (human) (rec.) (highly active)
    Specificity
    Full length human arginase I.
    Cross-Reactivity
    Human
    Characteristics
    Full length human arginase I.
    Purity
    >90 % (SDS-PAGE)
    Biological Activity Comment
    1.6 ±0.2U/μg protein. One unit is defined as the amount of enzyme that converts 1μmol of L-arginine to L-ornithine and urea per min. at 37°C, pH 9.5 (according to protocol from R.T. Schimke, et al., J. Biol. Chem. 238, 1012 (1963)).
    Top Product
    Discover our top product ARG1 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.2 μg/μL
    Buffer
    In 10 mM TRIS-HCl, pH 7.5, containing 1 mM beta-mercaptoethanol, 1 mM MnCl2 and 50 % glycerol.
    Handling Advice
    Avoid freeze/thaw cycles.
    Storage
    -20 °C,-80 °C
    Storage Comment

    Short Term Storage: -20°C

    Long Term Storage: -80°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

    Expiry Date
    12 months
  • Target
    Liver Arginase (ARG1) (Arginase, Liver (ARG1))
    Alternative Name
    Arginase I (ARG1 Products)
    Background

    EC 3.5.3.1, ARG1, Arginase 1, Type I Arginase, Liver-type Arginase, L-Arginase

    Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.

    Molecular Weight
    34.7kDa
    UniProt
    P05089
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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