SIGIRR Protein (AA 1-118) (Fc Tag)

Catalog No. ABIN6253499

Recombinant SIGIRR protein expressed in HEK-293 Cells.

Quick Overview for SIGIRR Protein (AA 1-118) (Fc Tag) (ABIN6253499)

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >90 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 1-118

Purification tag / Conjugate: This SIGIRR protein is labelled with Fc Tag.

Purpose: SIGIRR (human):Fc (human) (rec.)

Specificity: Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.

Cross-Reactivity: Human

Characteristics: Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.

Sterility: Sterile filtered

Endotoxin Level: <0.06EU/μg purified protein (LAL test).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Expiry Date: 6 months

Target Details

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Alternative Name: SIGIRR

Background:

Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

Molecular Weight: ~50kDa (SDS-PAGE)

Pathways: Toll-Like Receptors Cascades