ITGA4/ITGB7 Protein (AA 34-977) (His tag)

Catalog No. ABIN6253569

This Recombinant ITGA4/ITGB7 protein is produced in HEK-293 Cells.

Quick Overview for ITGA4/ITGB7 Protein (AA 34-977) (His tag) (ABIN6253569)

Target: ITGA4/ITGB7 (ITGA4 / ITGB7) (Integrin Alpha4-Beta7 (ITGA4 / ITGB7))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 34-977

Purification tag / Conjugate: This ITGA4/ITGB7 protein is labelled with His tag.

Sequence: AA 34-977

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM NaCl, pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: ITGA4/ITGB7 (ITGA4 / ITGB7) (Integrin Alpha4-Beta7 (ITGA4 / ITGB7))

Alternative Name: Integrin alpha 4 beta 7

Background: Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Molecular Weight: 111.4 kDa (ITGA4) & 81.8 kDa (ITGB7)