LRG1 Protein (AA 36-347) (His tag)
Quick Overview for LRG1 Protein (AA 36-347) (His tag) (ABIN6388182)
Target
See all LRG1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 36-347
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Purification tag / Conjugate
- This LRG1 protein is labelled with His tag.
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Sequence
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VTLSPKD CQVFRSDHGS SISCQPPAEI PGYLPADTVH LAVEFFNLTH LPANLLQGAS KLQELHLSSN GLESLSPEFL RPVPQLRVLD LTRNALTGLP PGLFQASATL DTLVLKENQL EVLEVSWLHG LKALGHLDLS GNRLRKLPPG LLANFTLLRT LDLGENQLET LPPDLLRGPL QLERLHLEGN KLQVLGKDLL LPQPDLRYLF LNGNKLARVA AGAFQGLRQL DMLDLSNNSL ASVPEGLWAS LGQPNWDMRD GFDISGNPWI CDQNLSDLYR WLQAQKDKMF SQNDTRCAGP EAVKGQTLLA VAKSQ -
Purification
- > 95% by SDS-PAGE
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Endotoxin Level
- < 1 EU per 1ug of protein (determined by LAL method)
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Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) (AA 72-383) (Active) protein (His tag)
LRG1 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) (AA 33-342) (Active) protein (His tag)LRG1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) (AA 37-347) protein (GST tag)LRG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) (AA 36-347) protein (His tag)LRG1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Leucine-Rich alpha-2 Glycoprotein 1 (LRG1) (AA 36-347) protein (His tag)LRG1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. IA, ScA, ADA, AM
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Buffer
- Phosphate-Buffered Saline ( pH 7.4) containing 10 % glycerol
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- LRG1 (Leucine-Rich alpha-2 Glycoprotein 1 (LRG1))
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Alternative Name
- LRG1
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Background
- LRG1, also known as leucine-rich alpha-2-glycoprotein, is a member of leucine-rich repeat (LRR) family. It is neutrophilic expressed during granulocyte differentiation. It has been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. It binds directly to the TGF-beta accessory receptor endoglin, which, in the presence of TGF-beta1, results in promotion of the pro-angiogenic Smad1/5/8 signaling pathway. It promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation. It is a key physiological regulator of dendrite complexity of hippocampal pyramidal neurons. It physically interacts with TrkB and attenuates BDNF signaling. Recombinant human LRG1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Molecular Weight
- 35.4 kDa (321aa)
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NCBI Accession
- NP_443204
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Pathways
- Brown Fat Cell Differentiation
Target
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