Prolactin Protein (PRL) (AA 30-228)
Quick Overview for Prolactin Protein (PRL) (AA 30-228) (ABIN5777732)
Target
See all Prolactin (PRL) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 30-228
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Sequence
- MQPLPICSAG DCQTSLRELF DRVVILSHYI HTLYTDMFIE FDKQYVQDRE FMVKVINDCP TSSLATPEDK EQALKVPPEV LLNLILSLVQ SSSDPLFQLI TGVGGIQEAP EYILSRAKEI EEQNKQLLEG VEKIISQAYP EAKGNGIYFV WSQLPSLQGV DEESKILSLR NTIRCLRRDS HKVDNFLKVL RCQIAHQNNC
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Endotoxin Level
- < 1.0 EU per 1ug of protein (determined by LAL method)
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Biological Activity Comment
- Measured in a cell proliferation assay using Nb2-11 Rat lymphoma cells. The ED50 for this effect is less or equal 3 ng/ml.
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Prolactin (PRL) (Active) protein
PRL Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Prolactin (PRL) protein (His tag)PRL Origin: Sheep Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Prolactin (PRL) (AA 29-227) protein (Fc Tag)PRL Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Prolactin (PRL) protein (His tag)PRL Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 92 % as determined by SDS-PAGE
Prolactin (PRL) (AA 29-227) protein (GST tag)PRL Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Prolactin (PRL) (AA 29-227) protein (Fc Tag,AVI tag,Biotin)PRL Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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Bioactivity Validated
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Liquid. In Phosphate buffered saline ( pH 7.4)
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Prolactin (PRL)
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Alternative Name
- Prolactin
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Background
- Prolactin, also known as prl, is a hormone synthesized and secreted by lactotrope cells in the adenohypophysis (anterior pituitary gland). Prolactin has many effects, the most significant of which is to stimulate the mammary glands to produce milk (lactation). Increased serum prolactin during pregnancy causes enlargement of the mammary glands of the breasts and increases the production of milk. Recently, prolactin has demonstrated broader roles in breast cancer development, regulation of reproductive function, and immuno-regulation. Recombinant mouse Prolactin, was expressed in E.coli and purified by using conventional chromatography techniques.
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Molecular Weight
- 22.7kDa (200aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_035294
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UniProt
- Q9CPQ2
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Pathways
- JAK-STAT Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Protein targeting to Nucleus
Target
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