COMT Protein (AA 51-271)
Quick Overview for COMT Protein (AA 51-271) (ABIN666744)
Target
See all COMT ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 51-271
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Sequence
- MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P
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Characteristics
- COMT, 51-271 aa, Human, Recombinant, E.coli
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Purification
- > 95% by SDS-PAGE
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Endotoxin Level
- < 1 EU per 1ug of protein (determined by LAL method)
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Catechol-O-Methyltransferase (COMT) (AA 1-271) protein (His tag)
custom-made COMT Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Catechol-O-Methyltransferase (COMT) (AA 1-265) protein (His tag)custom-made COMT Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Catechol-O-Methyltransferase (COMT) (AA 51-271) protein (His-IF2DI Tag)COMT Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Catechol-O-Methyltransferase (COMT) (AA 1-182) protein (GST tag)COMT Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 20 mM Tris-HCl buffer ( pH 8.0) containing 1 mM MgCl2, 10 % glycerol
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- COMT (Catechol-O-Methyltransferase (COMT))
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Alternative Name
- COMT
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Background
- Catechol-O-methyltrasferase (COMT) is an enzyme that catalyses the transfer of the methyl group of S-adenosylmethionine (SAM) into catechol substrates such as levodopa, dopamine, epinephrine, and norepinephirine in the presence of Mg2+. COMT appears to be located in the postsynaptic neuron and plays roles in the metabolism of catechol estrogens and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson's disease. Recombinant human COMT protein was expressed in E. coli and purified by using conventional chromatography techniques.
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Molecular Weight
- 24.4 kDa (221aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_000745
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Pathways
- Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome
Target
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