RAN Protein (AA 1-216) (His tag)

Catalog No. ABIN667788

Product Details

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Protein Type: Recombinant

Protein Characteristics: AA 1-216

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This RAN protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: RAN, 1-216aa, Human, His tag, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Storage: 4 °C

Target Details

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Alternative Name: RAN (RAN Products)

Background: RAN, member RAS oncogene family, also known as RAN, is a small GTPase of the Ras superfamily that controls nucleocytoplasmic transport. It is involved in the directionality of the process that is regulated by GTP hydrolysis. Ran shuttles between the nucleus and the cytoplasm. Unlike many other regulatory GTPases, Ran is not posttranslationally modified so that it can be targeted to the subcellular compartment where it acts. Rather, RanGTP has been thought to be localized by the differential localization of Ran regulators. Recombinant human RAN, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: ARA24, Gsp1, TC4, RAN, member RAS oncogene family, Androgen receptor associated protein 24, ARA 24, GTP binding nuclear protein RAN, GTPase Ran, LPS, RAN member RAS oncogene family, Ras like protein TC4, RASL2 8,. NCBI no.: NP_006316

Molecular Weight: 26.5 kDa (236aa), confirmed by MALDI-TOF

Pathways: Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus