RAN Protein (AA 2-219) (His-SUMO Tag)

Catalog No. ABIN5710886

Recombinant RAN protein expressed in Escherichia coli (E. coli).

Quick Overview for RAN Protein (AA 2-219) (His-SUMO Tag) (ABIN5710886)

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Protein Type: Recombinant

Origin: Saccharomyces cerevisiae

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Protein Characteristics: AA 2-219

Purification tag / Conjugate: This RAN protein is labelled with His-SUMO Tag.

Sequence: SAPAANGEVP TFKLVLVGDG GTGKTTFVKR HLTGEFEKKY IATIGVEVHP LSFYTNFGEI KFDVWDTAGQ EKFGGLRDGY YINAQCAIIM FDVTSRITYK NVPNWHRDLV RVCENIPIVL CGNKVDVKER KVKAKTITFH RKKNLQYYDI SAKSNYNFEK PFLWLARKLA GNPQLEFVAS PALAPPEVQV DEQLMQQYQQ EMEQATALPL PDEDDADL

Purification: SDS-PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Alternative Name: GSP1

Background: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1.

Molecular Weight: 40.66 kDa

UniProt: P32835

Pathways: Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus