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c-FOS Protein (GST tag)

This Recombinant c-FOS protein is expressed in Insect cells (Sf9).
Rockland
Catalog No. ABIN6699563
Supplier Product No.: 009-001-r95s

Quick Overview for c-FOS Protein (GST tag) (ABIN6699563)

Target

See all c-FOS (c-Fos) Proteins
c-FOS (c-Fos) (c-Fos)

Protein Type

Recombinant

Origin

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Human

Source

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Insect cells (Sf9)

Application

Western Blotting (WB)

Purity

>90%
  • Purification tag / Conjugate

    This c-FOS protein is labelled with GST tag.

    Supplier Product No.

    009-001-r95s

    Supplier

    Rockland

    Purpose

    FOS recombinant protein-GST fusion protein

    Purification

    Recombinant full-length human FOS was expressed by baculovirus in Sf9 insect cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >90% by densitometry.
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  • Application Notes

    Application Note: FOS Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. FOS Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~78 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

    Western Blot Dilution: User Optimized

    Other: Kinase Assay-User Optimized

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.2 μg/μL

    Buffer

    FOS Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.

    Storage

    -80 °C

    Storage Comment

    Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    c-FOS (c-Fos) (c-Fos)

    Alternative Name

    FOS

    Background

    Synonyms: AP-1, c-FOS, Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7

    Background: FOS is a member of the FOS gene family that consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. FOS gene encodes a leucine zipper protein that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation (1). In some cases, expression of the FOS gene has also been associated with apoptotic cell death. FOS overexpression leads to decreased phosphorylation and dimerization of STAT1, which in turn downregulates p21 gene expression (2). This regulatory pathway may enhance the proliferation of lymphocytes in rheumatoid arthritis patients. FOS Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, and Neurobiology research.

    NCBI Accession

    NM_005252

    Pathways

    S100 Proteins
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