HHLA2 Protein (AA 23-344) (Fc Tag)

Catalog No. ABIN6809928

This Recombinant HHLA2 protein is produced in HEK-293 Cells.

Quick Overview for HHLA2 Protein (AA 23-344) (Fc Tag) (ABIN6809928)

Target: HHLA2 (HERV-H LTR-Associating 2 (HHLA2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >90 % as determined by reduced SDS-PAGE.

Product Details

Protein Characteristics: AA 23-344

Purification tag / Conjugate: This HHLA2 protein is labelled with Fc Tag.

Sequence: AA 23-344

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: HHLA2 (HERV-H LTR-Associating 2 (HHLA2))

Alternative Name: B7-H7

Background: B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.

Molecular Weight: 63.4 kDa

NCBI Accession: NP_009003