LRP6 Protein (AA 20-630) (Fc Tag)

Catalog No. ABIN6938849

Recombinant LRP6 protein expressed in HEK-293 Cells.

Quick Overview for LRP6 Protein (AA 20-630) (Fc Tag) (ABIN6938849)

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 20-630

Purification tag / Conjugate: This LRP6 protein is labelled with Fc Tag.

Endotoxin Level: Less than 0.1 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Storage: -20 °C

Target Details

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Alternative Name: LRP-6

Background: LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

Molecular Weight: 95.8 kDa

NCBI Accession: NP_002327

Pathways: WNT Signaling, Tube Formation